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What is Gina and how does it treat vaginal atrophy?

Gina is the only treatment available without a prescription that treats the cause of vaginal atrophy after the menopause1

What is Gina?

Gina is a low-dose vaginal oestrogen tablet that treats the cause of vaginal atrophy after the menopause, as well as the symptoms.1

Gina is clinically proven to restore vaginal health by replenishing moisture and balancing vaginal pH1,2

Who can use Gina?

Gina is indicated for the treatment of vaginal atrophy due to oestrogen deficiency in postmenopausal women aged 50 years and above, who have not had a period for at least 1 year1

Download the Gina Checklist

  • The go-to resource on whether Gina is right for your patient, including when to refer to a GP
Download Pharmacy Checklist

When to refer women to their GP?

Women with the following symptoms, conditions and medications may require assessment by their GP to confirm suitability for Gina before treatment.

  1. Women who have a history of the following conditions:
    • Endometriosis, unless they have previously been prescribed a local oestrogen therapy and there have been no changes to their health status since their last prescription, and no recent symptoms of endometriosis.
    • Endometrial hyperplasia unless they have: previously been prescribed a local oestrogen therapy and there have been no changes to their health status since their last prescription, or had a hysterectomy.
  2. Women on the following medication:
    • Women receiving hormonal therapy, including systemic HRT, unless they have previously been prescribed a local oestrogen therapy for concurrent use and their health status has not changed since their last local oestrogen therapy prescription.
    • Women currently using a different local oestrogen therapy, unless they have been using this for >3 months at the recommended dose and their symptoms are adequately controlled, and there have been no changes to their health status since their last prescription.
  3. Women with a vaginal infection:
    • Prior to starting treatment, should be treated before starting treatment with Gina.
    • During treatment with Gina, that cannot be managed by pharmacy should be referred to their GP for treatment.

For more information please see the Pharmacy Guide & Checklist.

How does Gina work?

Gina is a locally-administered, low-dose vaginal estradiol tablet that replaces lost oestrogen where it’s needed, and has low-level systemic absorption.1,3

Gina starts restoring vaginal health after 2 weeks, and by week 8, women can get relief of vaginal and vulval symptoms, including:1,2,3

Vaginal dryness1,2
Itching3
Burning3
Soreness3
Painful sex3
Please refer to the Pharmacy Guide for more details on symptom relief

Gina contains 10 micrograms of estradiol and, if used continuously for one year, delivers an oestrogen dose of 1.14mg per year.4 This oestrogen dose is roughly equivalent to 1 tablet of oral HRT.5

Treating vaginal atrophy
with Gina

Gina comes in a hygienic, pre-loaded applicator designed to deliver the correct dose every time.1

Gina dosing:

example day of week phasing

Pack contains 24 doses

Advise women that VA is chronic and progressive and symptoms are likely to return if treatment is stopped. Women can continue to use Gina as long as they wish (unless they are no longer suitable) which may be years, if appropriate.

Initiation and continuation of treatment should be at the lowest effective dose for the shortest duration. You should discuss this with your patients when they purchase a new supply of Gina (every 3 months).

Visit the Learning Resources Page to explore training for pharmacy teams on vaginal atrophy and how to support women with Gina

Visit the Pharmacy Network

1. Gina Summary of Product Characteristics.

2. Simon J et al. Obstet & Gynecol 2008;112:1053-1061.

3. Panay N et al. Menopause International 2012;18:15–19.​

4. Simon JA et al. Climacteric 16:sup 1, 37-43

5. Elleste Solo 1mg tablet. Summary of Product Characteristics 2020.